[Download] "Frequency of GSTT1*0 Genotype As a Non-Conjugator Phenotype in a Group of Healthy Iranian People (Glutathione S-Transferase Theta-1) (Report)" by Journal of Biomedical Science and Engineering (JBiSE) * eBook PDF Kindle ePub Free

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eBook details

• Title: Frequency of GSTT1*0 Genotype As a Non-Conjugator Phenotype in a Group of Healthy Iranian People (Glutathione S-Transferase Theta-1) (Report)
• Author : Journal of Biomedical Science and Engineering (JBiSE)
• Release Date : January 01, 2011
• Genre: Engineering,Books,Professional & Technical,
• Pages : * pages
• Size : 224 KB

Description

1. INTRODUCTION Glutathione S-transferase T1 detoxifies the genotoxic compounds containing an electrophilic center and protects from DNA damage. GSTT protects cells by catalyzing the conjugation of toxic and carcinogenic electrophilic molecules with glutathione that are excreted through kidney [1]. It is hypothesized that reduced GSTs activity is associated with higher incidence of cancer that seems a results of decreased elimination of electrophilic carcinogens [2] Inter-individual differences in the capacity of detoxifying toxins, cancer susceptibility, and drug resistance maybe mediated in part through polymorphic variability in the bioactivation and detoxification of occupational carcinogens, environmental pollutants [3]. Several studies have found GSTs consistency in cancer susceptibility genes [4-6] and few studies report the relation of toxicity of chemotherapeutic agents with GSTs inactive genotype [7]. Other studies have shown that GST theta null genotypes individuals are more susceptible to the mutagenic effects of some GSTT1 substrates [8].

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